Curcumin (diferoylmethane)

"Indian Saffron", Curcuma longa http://en.wikipedia.org/wiki/Turmeric

Maustekurkuma (Curcuma longa) on inkiväärikasveihin kuuluva ruohovartinen kasvi. Sen juurista saatavaa maustetta kutsutaan kurkumaksi. Juuri kuivataan ja jauhetaan, jolloin tuloksena on voimakkaan keltainen maustejauhe, jota käytetään usein currymausteseoksen osana ja muussa eteläaasialaisessa ruoanlaitossa. Kurkumaa käytetään myös keltaisen värin antajana eräissä sinapeissa sekä jopa kankaiden värjäykseen.

Maustekurkumasta uutetaan kurkumiinia, jota käytetään elintarvikkeissa väriaineena. Kurkumiinin E-koodi on E 100.

"Intian sahrami ", käytetty myös mausteväärennöksiin sahramin sijasta, kertoo Wikipedia.

http://www.ncbi.nlm.nih.gov/pubmed/20924967

Nutr Cancer. 2010;62(7):919-30. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.

Goel A, Aggarwal BB.

Source

Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA.

Abstract

Curcumin (diferuloylmethane), the yellow pigment in Indian saffron (Curcuma longa; also called turmeric, haldi, or haridara in the East and curry powder in the West), has been consumed by people for centuries as a dietary component and for a variety of proinflammatory ailments. Extensive research within the last decade in cell culture and in rodents has revealed that curcumin can sensitize tumors to different chemotherapeutic agents including doxorubicin, 5-FU, paclitaxel, vincristine, melphalan, butyrate, cisplatin, celecoxib, vinorelbine, gemcitabine, oxaliplatin, etoposide, sulfinosine, thalidomide, and bortezomib. Chemosensitization has been observed in cancers of the breast, colon, pancreas, gastric, liver, blood, lung, prostate, bladder, cervix, ovary, head and neck, and brain and in multiple myeloma, leukemia, and lymphoma. Similar studies have also revealed that this agent can sensitize a variety of tumors to gamma radiation including glioma, neuroblastoma, cervical carcinoma, epidermal carcinoma, prostate cancer, and colon cancer. How curcumin acts as a chemosensitizer and radiosensitizer has also been studied extensively. For example, it downregulates various growth regulatory pathways and specific genetic targets including genes for NF-κB, STAT3, COX2, Akt, antiapoptotic proteins, growth factor receptors, and multidrug-resistance proteins. Although it acts as a chemosensitizer and radiosensitizer for tumors in some cases, curcumin has also been shown to protect normal organs such as liver, kidney, oral mucosa, and heart from chemotherapy and radiotherapy-induced toxicity. The protective effects of curcumin appear to be mediated through its ability to induce the activation of NRF2 and induce the expression of antioxidant enzymes (e.g., hemeoxygenase-1, glutathione peroxidase, modulatory subunit of gamma-glutamyl-cysteine ligase, and NAD(P)H:quinone oxidoreductase 1, increase glutathione (a product of the modulatory subunit of gamma-glutamyl-cysteine ligase), directly quench free radicals, and inhibit p300 HAT activity. These preclinical studies are expected to lead to clinical trials to prove the potential of this age-old golden spice for treating cancer patients.

PMID:

20924967

[PubMed - indexed for MEDLINE]

Curcumin, kurkmeija

http://en.wikipedia.org/wiki/Curcumin

Karrin väriaine Curcuma longa, Turmeric

Mitä gurkumin, kurkmeja, on?

Tästä on oma nettikohtansa joka kertoo tämän mausteväriaineen eduista. Tämä on E-sarjan lisäaineita. Ruotsalainen luettelo kertoo: E 100 - Kurkumin (väriaine, färgämne) E-nummer Färgämnen. Funktion Färgämne som ger gulgulorange kulör. Tillverkning Extraheras ur roten av växten Curcuma longa, som i mald form kallas gurkmeja. Användningsområde Används i t.ex. curry, industriost och margarin. Kända hälsorisker: -.

Suomeksi: Kurkumiini on väriaine, joka antaa keltaoranssin värin ruokaan. Sitä uutetaan Curcuma longa nimisestä kasvista ja jauhetussa muodossaan sitä sanotaan kurkmeijaksi. Sitä käytetään karrissa, teollisessa juustossa ja margariinissa. Sillä ei tunneta olevan terveydellisiä haittoja.

Ladda ner E-nummer i PDF >> http://www.curcumin.net/

What is Curcumin?

Who said something that tastes good can't be good for you? Curcumin (Curcuma longa) is the source of the spice Turmeric, and is used in curries and other spicy dishes from India, Asia, and the Middle East. Curcumin is what gives the Curry its characteristic bright yellow color and strong taste. If curry is too spicy for your tummy, then you can still obtain the benefits of Curcumin by taking it as a nutritional supplement in convenient capsule form. Or, if you like the heat, break the capsule open and sprinkle it on your food.

Like many herbal remedies, people first used Curcumin as a food and later discovered that it also had impressive medicinal qualities. Over the centuries, this spice has been used as a pain relieving, anti-inflammatory agent to relieve pain and inflammation in the skin and muscles. It has served as a treatment for jaundice, menstrual difficulties, hematuria, hemorrhage, colic, and flatulence. In modern times, research has focused on Curcumin's antioxidant, anti-inflammatory, anticarcinogenic, and antimicrobial properties, and on its use in cardiovascular disease, gastrointestinal disorders, and as a treatment for the liver.

The food we eat has a direct effect on our health, even if that food is something as seemingly insignificant as a spice. Research on families immigrating from India to the United States may reflect the importance of Curcumin in the diet. It is well documented that cancer rates in India are lower than those seen in Western countries. However, studies of Indian immigrants in Western societies indicate that rates of cancer and other chronic diseases, such as coronary heart disease and diabetes, increase dramatically after a generation in the adopted country. Change of diet is among the factors that may be responsible for the changing disease rates. In a study conducted by the United States National Cancer Institute, the researchers noted, "Of particular interest for cancer prevention is the role of turmeric (Curcumin), an ingredient in common Indian curry spice.[1]

Curcumin

David Kramer kirjoittaa kurkumiinista seuraavaa:
Sitä ehdotetaan käytettäväksi AD sairautta vastaan. Eräs tutkimus oli havainnut, että kurkumiiniseos on vaikutukseltaan anti-amyloidogeeninen ja moduloi BACE1 ja APP proteiineja. APP on beta-amyloidin edeltäjäproteiini., josta voi haitallinen Abeeta muoto kehittyä silloin kun BACE1 entsyymi ja gammasekretaasi käyvät sitä pilkkomaan.

Aihepiiri Alzheimer's Disease. beta-Amylase ELISA kit: Current study suggest curcumin for Alzheimer's disease treatment

The authors of a recent study used an Abeta ELISA Kit that is available at antibodies-online. The published study shows that some curcumin mixes have a potent anti-amyloidogenic effect via modulation of BACE1 and APP and hence may be promising for AD treatment and prevention. There is evidence that a hallmark of Alzheimer's disease (AD) is the accumulation of beta-amyloid protein (Abeta). Abeta is generated from the beta-amyloid precursor protein (APP) through the proteolysis of beta-site APP cleaving enzyme 1 (BACE1) and gamma-secretase.

• Tässä tutkimuksessa tutkittiin erilaisten KURKUMINOIDIEN vaikutusta beta-amyloidiproteiiniin, sen edeltäjäproteiiniin APP ja sitä pilkkovaan entsyymiin : Aβ₄₂, APP, BACE1.

The study can be found here:

Source: Neurosci Lett. 2010 Aug 17. The inhibitory effects of different curcuminoids on beta-amyloid protein, beta-amyloid precursor protein and beta-site amyloid precursor protein cleaving enzyme 1 in swAPP HEK293 cells. Liu H, et al

• KURKUMIINISEOS käsitti seuraavat kurkuminoidit

Kurkumiini, (Cur)
Demetoksikurkumiini( DMC)
Bisdemetoksikurkumiini (BDMC)

Curcumin mix has potent anti-amyloidogenic effect and shows great promise for AD treatment and prevention. The present study was conducted to examine the effects of curcumin mix and its different curcuminoids including curcumin (Cur), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) on Aβ₄₂, APP and BACE1.

• Kurkumiini(Cur), mutta ei muut kurkuminoidit) vähensivät APP proteiinin ilmenemistä ja Abeetan tuottoa. Mikään kurkuminoidi ei voinut kuitenkaan vähentää APP mRNA:n ilmenemistä. BDMC vähensi pilkkovan entsyymin BACE1 mRNA:ta ja proteiinia. DMC vaikutti ainoastaan BACE1 mRNA expressioon.

We found that Cur was the most active curcuminoid fraction in suppressing Aβ₄₂ production and the order of inhibitory potency of other curcuminoids was DMC > curcumin mix > BDMC. Cur, but not other curcuminoids, could reduce APP protein expression and none of curcuminoids affected APP mRNA level. BDMC could reduce BACE1 mRNA and protein levels, while DMC only affected BACE1 mRNA expression.

• Johtopäätöksenä kurkumiinin anti-amyloidogeeninen vaikutus välittyy APP modulaation kautta. BDMC:n antiamyloidogeeninen vaikutusvälittyy pilkkovan entsyymin BACE1 kautta.
  

Our data indicate that the anti-amyloidogenic effect of Cur may be mediated through the modulation of APP, while the anti-amyloidogenic effect of BDMC may be mediated through the modulation of BACE1.

Suomennettu 8 helmikuuta 2011

06.09.2010

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David Kitz Kramer

LÄHDE: Research News .