- Suomalainen Wiki sanoo näin:
Fenyylialaniinihydroksylaasi eli PAH löytyi ensimmäisenä.[1] Todettiin, että tetrahydrobiopteriinin puute saa aikaan harvinaisen aineenvaihdunnan häiriön, joka lisää veren fenyylialaniinipitoisuutta. Fenyylialamiinin kertyminen elimistöön aiheuttaa kehitysvammaisuutta ja muita vakavia terveysongelmia.
Tetrahydrobiopteriini ja Fe2+-ioni ovat tryptofaanihydroksylaasin toiminnalle välttämättömiä koentsyymejä [2] jotka vaikuttavat serotoniiniaineenvaihdunnan kautta muun muassa keskushermoston toimintaa.
Saunassa kudosten lämmetessä elimistöön syntyy tetrahydrobiopteriinia, jota tarvitaan verisuonten normaalin toiminnan ylläpitämisessä.
Tetrahydrobiopteriinista käytetään myös nimeä 5,6,7,8-tetrahydrobiopteriini.
Tetrahydrobiopteriinin kemiallinen kaava on C9H15N5O3, moolimassa 241,247 g/mol ja CAS-numero 17528-72-2.
- Vuodelta 2007 on seuraava laaja artikkeli:
- KUVA , Fenylalaniini, Tyrosiini, DOPA aineenvaihdunta alue
Myös: tryptofaanin aineenvaihdunta-alue
Tryptophan hydroxylase (TPH) is an enzyme involved in the synthesis of the neurotransmitter serotonin. TPH catalyzes the following chemical reaction L-tryptophan + tetrahydrobiopterin + O2 5-Hydroxytryptophan + dihydrobiopterin + H2O It employs one additional cofactor, iron.
Jos nukkuu hyvin ei voi suorittaa hyvä motorista prestaatiota samaan aikaan.
http://cat.inist.fr/?aModele=afficheN&cpsidt=20533018
- Myös tämä dihydropteriinista BH2
J Phys Chem A. 2007 May 24;111(20):4280-8. Epub 2007 May 3. Singlet oxygen (O2(1Deltag)) quenching by dihydropterins.
Source
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CONICET, Boulevard 113 y 64 (1900) La Plata, Argentina.Abstract
Pterins
belong to a class of heterocyclic compounds present in a wide range of
living systems. They participate in relevant biological functions and
are involved in different photobiological processes. Dihydropterins are
one of the biologically active forms of pterins. The photoinduced
production and quenching of singlet oxygen (1O2) by a series of
dihydropterins (7,8-dihydrobiopterin (DHBPT), 7,8-dihydroneopterin
(DHNPT), 6-formyl-7,8-dihydropterin (FDHPT), sepiapterin (SPT),
7,8-dihydrofolic acid (DHFA), and 7,8-dihydroxanthopterin (DHXPT)) in
aqueous solution at physiological pH ( approximately 7) were
investigated, and the quantum yields of 1O2 production (PhiDelta) and
rate constants of total quenching (kt) of 1O2 were determined.
Studied compounds do not produce 1O2 under UV-A irradiation and are very efficient 1O2 quenchers. The chemical reactions between 1O2 and dihydropterin derivatives were investigated, and the corresponding rate constants (kr) were found to be particularly high.
The oxidized pterin derivatives, biopterin (BPT), neopterin (NPT), 6-formylpterin (FPT), and folic acid (FA), were identified and quantified during the reaction of 1O2 with DHBPT, DHNPT, FDHPT, and DHFA, respectively.
Besides the oxidation of the dihydropyrazine ring to yield the corresponding oxidized pterins, a second oxidation pathway, leading to fragmentation of the dihydropterin and formation of non-pterinic products, was identified. Mechanisms and biological implications are discussed.
Studied compounds do not produce 1O2 under UV-A irradiation and are very efficient 1O2 quenchers. The chemical reactions between 1O2 and dihydropterin derivatives were investigated, and the corresponding rate constants (kr) were found to be particularly high.
The oxidized pterin derivatives, biopterin (BPT), neopterin (NPT), 6-formylpterin (FPT), and folic acid (FA), were identified and quantified during the reaction of 1O2 with DHBPT, DHNPT, FDHPT, and DHFA, respectively.
Besides the oxidation of the dihydropyrazine ring to yield the corresponding oxidized pterins, a second oxidation pathway, leading to fragmentation of the dihydropterin and formation of non-pterinic products, was identified. Mechanisms and biological implications are discussed.
- PMID:
- 17474729
- [PubMed - indexed for MEDLINE]
- Jos sydänlihassolun biopteriinin synteesi on vajeista , sepiapteriinimuodon anto voi nostaa BH4 ja BH2 pitoisuutta.
- http://www.ncbi.nlm.nih.gov/pubmed/18835915
Inga kommentarer:
Skicka en kommentar