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1.
Tyagi AK, Prasad S, Majeed M, Aggarwal BB.
Phytomedicine. 2017 Oct 15;34:171-181. doi: 10.1016/j.phymed.2017.08.021. Epub 2017 Aug 31.
- PMID:
- 28899500
2.
Lee HJ, Kang SM, Jeong SH, Chung KH, Kim BI.
Photodiagnosis Photodyn Ther. 2017 Sep 7. pii: S1572-1000(17)30300-9. doi: 10.1016/j.pdpdt.2017.09.003. [Epub ahead of print]
- PMID:
- 28890211
3.
Pan MH, Wu JC, Ho CT, Badmaev V.
J Complement Integr Med. 2017 May 12;14(3). pii: /j/jcim.2017.14.issue-3/jcim-2015-0107/jcim-2015-0107.xml. doi: 10.1515/jcim-2015-0107.
Background Immunity and Longevity Methods A water extract of Curcuma longa
(L.) [vern. Turmeric] roots (TurmericImmune™) standardized for a
minimum 20 % of turmeric polysaccharides ukonan A, B, C and D was
evaluated for its biological properties in in vitro tissue culture
studies. Results The water extract of turmeric (TurP) exhibited
induced-nitric oxide (NO) production in RAW264.7 macrophages. These
results suggested the immunomodulatory effects of TurP. In addition, the
polysaccharides up-regulated function of telomerase reverse
transcriptase (TERT) equally to the phenolic compound from turmeric,
curcumin. Conclusions The ukonan family of polysaccharides may assist in
promoting cellular immune responses, tissue repair and lifespan by
enhancing immune response and telomere function
4.
Vaughn AR, Haas KN, Burney W, Andersen E, Clark AK, Crawford R, Sivamani RK.
Phytother Res. 2017 Sep 7. doi: 10.1002/ptr.5912. [Epub ahead of print] Review.
Turmeric root (Curcuma longa)
is predominantly used as a spice, but has also long been known to
possess antimicrobial, analgesic, antiinflammatory, and anticancer
properties. One predominant group of active compounds in turmeric are
curcuminoids, namely bright yellow-pigmented curcumin. While modern
science has yet to fully investigate the therapeutic claims of turmeric
and its derivatives, results have proven promising in decreasing pain
and inflammation in arthritis, improving insulin sensitivity in
diabetes, and even curing a variety of infections. The purpose of this
review is to discuss the potential for curcumin as an agent against
microbial infections, with a special focus on the skin and in the
development of bacterial biofilms. Curcumin has demonstrated
bactericidal efficacy against a variety of infections when administered
with antibiotics in several clinical studies, with consistent
antimicrobial activity demonstrated in vitro, as well as in urinary
tract infections, gingival infections, and chronic wound infections.
Hypothesized mechanisms of action include curcumin's ability to perturb
bacterial membranes, disturb protofillament assembly, and even impair
bacterial virulence factors. Further investigation is needed to fully
understand which organisms are most susceptible to the effects of
curcumin and how curcumin can be implemented in dermatology to treat
skin conditions such as chronic wounds and acne vulgaris. Copyright ©
2017 John Wiley & Sons, Ltd.
5.
Sumathi CS.
Cardiovasc Hematol Agents Med Chem. 2017 Aug 30. doi: 10.2174/1871525715666170830130555. [Epub ahead of print]
- PMID:
- 28875835
6.
Gomes GS, Maciel TR, Piegas EM, Michels LR, Colomé LM, Freddo RJ, Ávila DS, Gundel A, Haas SE.
AAPS PharmSciTech. 2017 Sep 5. doi: 10.1208/s12249-017-0854-6. [Epub ahead of print]
- PMID:
- 28875471
7.
Bosmali I, Ordoudi SA, Tsimidou MZ, Madesis P.
Food Res Int. 2017 Oct;100(Pt 1):899-907. doi: 10.1016/j.foodres.2017.08.001. Epub 2017 Aug 3.
- PMID:
- 28873765
8.
Del Grossi Moura M, Lopes LC, Biavatti MW, Kennedy SA, de Oliveira E Silva MC, Silva MT, de Cássia Bergamaschi C.
Phytother Res. 2017 Sep 5. doi: 10.1002/ptr.5910. [Epub ahead of print] Review.
- PMID:
- 28872719
9.
Ozawa H, Imaizumi A, Sumi Y, Hashimoto T, Kanai M, Makino Y, Tsuda T, Takahashi N, Kakeya H.
Biol Pharm Bull. 2017;40(9):1515-1524. doi: 10.1248/bpb.b17-00339.
Curcumin, a polyphenol derived from the rhizome of the naturally occurring plant Curcuma longa,
has various pharmacological actions such as antioxidant and
anti-inflammatory effects. In this paper, we evaluated the role of its
internal metabolite, curcumin β-D-glucuronide (curcumin monoglucuronide,
CMG), by investigating curcumin kinetics and metabolism in the blood.
Firstly, we orally administered highly bioavailable curcumin to rats to
elucidate its kinetics, and observed not only the free-form of curcumin,
but also, curcumin in a conjugated form, within the portal vein. We
confirmed that curcumin is conjugated when it passes through the
intestinal wall. CMG, one of the metabolites, was then orally
administered to rats. Despite its high aqueous solubility compared to
free-form curcumin, it was not well absorbed. In addition, CMG was
injected intravenously into rats in order to assess its metabolic
behavior in the blood. Interestingly, high levels of free-form curcumin,
thought to be sufficiently high to be pharmacologically active, were
observed. The in vivo antitumor effects of CMG following intravenous
injection were then evaluated in tumor-bearing mice with the HCT116
human colon cancer cell line. The tumor volume within the CMG group was
significantly less than that of the control group. Moreover, there was
no significant loss of body weight in the CMG group compared to the
control group. These results suggest that CMG could be used as an
anticancer agent without the serious side effects that most anticancer
agents havFree Article
10.
Bulfon C, Galeotti M, Volpatti D.
Fish Physiol Biochem. 2017 Sep 1. doi: 10.1007/s10695-017-0417-5. [Epub ahead of print]
- PMID:
- 28861641
11.
Chávez-Zamudio R, Ochoa-Flores AA, Soto-Rodríguez I, Garcia-Varela R, García HS.
Food Funct. 2017 Aug 31. doi: 10.1039/c7fo00933j. [Epub ahead of print]
- PMID:
- 28856361
12.
Saberi-Karimian M, Katsiki N, Caraglia M, Boccellino M, Majeed M, Sahebkar A.
Crit Rev Food Sci Nutr. 2017 Aug 30:0. doi: 10.1080/10408398.2017.1366892. [Epub ahead of print]
The discovery of Vascular Endothelial Growth Factor (VEGF), the key
modulator of angiogenesis, has triggered intensive research on
anti-angiogenic therapeutic modalities. Although several clinical
studies have validated anti-VEGF therapeutics, with few of them approved
by the U.S. Food and Drug Administration (FDA), anti-angiogenic therapy
is still in its infancy. Phytochemicals are compounds that have several
metabolic and health benefits. Curcumin, the yellow pigment derived
from turmeric (Curcuma longa
L.) rhizomes, has a wide range of pharmaceutical properties. It has
also been shown to inhibit VEGF by several studies. In this review, we
elaborate the effect of curcumin on VEGF and angiogenesis and its
therapeutic application
13.
Han S, Xu J, Guo X, Huang M.
Clin Exp Pharmacol Physiol. 2017 Aug 29. doi: 10.1111/1440-1681.12848. [Epub ahead of print]
- PMID:
- 28853207
14.
Chen M, Chang YY, Huang S, Xiao LH, Zhou W, Zhang LY, Li C, Zhou RP, Tang J, Lin L, Du ZY, Zhang K.
Mol Nutr Food Res. 2017 Aug 28. doi: 10.1002/mnfr.201700281. [Epub ahead of print]
- PMID:
- 28849618
15.
Akinyemi AJ, Oboh G, Ogunsuyi O, Abolaji AO, Udofia A.
Metab Brain Dis. 2017 Aug 28. doi: 10.1007/s11011-017-0100-7. [Epub ahead of print]
- PMID:
- 28849357
16.
Wang XP, Wang QX, Lin HP, Chang N.
Food Funct. 2017 Aug 29. doi: 10.1039/c7fo00555e. [Epub ahead of print]
- PMID:
- 28848967
17.
Yakoob J, Abbas Z, Mehmood MH, Tariq K, Saleem SA, Awan S, Malik A, Hamid S, Khan R, Jafri W.
J Integr Med. 2017 Sep;15(5):398-406. doi: 10.1016/S2095-4964(17)60359-5.
- PMID:
- 28844217
18.
Zhang HH, Zhang Y, Cheng YN, Gong FL, Cao ZQ, Yu LG, Guo XL.
Mol Carcinog. 2017 Aug 19. doi: 10.1002/mc.22718. [Epub ahead of print]
Hepatocellular carcinoma (HCC) has poor prognosis due to the advanced
disease stages by the time it is diagnosed, high recurrence rates and
metastasis. In the present study, we investigated the effects of
metformin (a safe anti-diabetic drug) and curcumin (a turmeric
polyphenol extracted from rhizome of Curcuma longa
Linn.) on proliferation, apoptosis, invasion, metastasis, and
angiogenesis of HCC in vitro and in vivo. It was found that co-treatment
of metformin and curcumin could not only induce tumor cells into
apoptosis through activating the mitochondria pathways, but also
suppress the invasion, metastasis of HCC cells and angiogenesis of
HUVECs. These effects were associated with downregulation of the
expression of MMP2/9, VEGF, and VEGFR-2, up-regulation of PTEN, P53 and
suppression of PI3K/Akt/mTOR/NF-κB and EGFR/STAT3 signaling.
Co-administration of metformin and curcumin significantly inhibited HCC
tumor growth than administration with metformin or curcumin alone in a
xenograft mouse model. Thus, metformin and curcumin in combination
showed a better anti-tumor effects in hepatoma cells than either
metformin or curcumin presence alone and might represent an effective
therapeutic strategy for HCC treatment.
19.
Win NN, Ito T, Ngwe H, Win YY, Prema, Okamoto Y, Tanaka M, Asakawa Y, Abe I, Morita H.
Fitoterapia. 2017 Aug 18;122:34-39. doi: 10.1016/j.fitote.2017.08.006. [Epub ahead of print]
- PMID:
- 28827004
20.
Nishidono Y, Fujita T, Kawanami A, Nishizawa M, Tanaka K.
Fitoterapia. 2017 Aug 18;122:40-44. doi: 10.1016/j.fitote.2017.08.007. [Epub ahead of print]
- PMID:
- 28827002
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